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PROMETEO II

PROtezione MEdiata da nanotecnologia antiossidanTE contro danni neuronali nello spaziO II
PROMETEO II

PROMETEO II from the Italian Space Agency (ASI) is a continuation of an ongoing study aimed to investigate how exposure to microgravity and space radiation affects cellular response to stress, as well as the neuroprotective effects of nanoparticles based on nanoceria. The results could help develop protective countermeasures for future spaceflight missions and build on efforts to develop therapeutic tools to treat neurodegenerative diseases on Earth.

PUBLICATION
Neuroprotective Effects of Cerium Oxide Nanoparticles During Spaceflight
  • Need to develop effective strategies to mitigate disruptions in redox homeostatis during spaceflight affecting central nervous system
  • Novel non-saccharide heparin mimetics effectively inhibit Cathepsin G (CatG), achieving high potency and selectivity
  • It was found to preserve extracellular matrix without affecting coagulation
  • This appears to have a promising therapeutic potential for neuro-inflammatory diseases during spaceflight